The HPV vaccine is routinely recommended for 11-12 year old boys and girls, along with the Tdap and MCV vaccines. However, HPV vaccination rates among American teenagers lag far behind those of Tdap and MCV. Pediatricians often encounter parents who refuse or delay the HPV vaccine, even if they are willing to consent to other childhood vaccines. Parents often have fears about the side effects of what they perceive to be a “new” vaccine, and question why a young pre-teen would need vaccination against a sexually transmitted virus. Research also demonstrates that providers often fail to make a strong recommendation for HPV vaccination at the age 11-12 visit, which potentiates the idea that the HPV vaccine is “optional” and not as important as other scheduled vaccines. This video provides up-to-date information about the burden of HPV-related disease, the rationale behind vaccinating pre-teens prior to sexual debut, the clear need for boys as well as girls to receive HPV vaccination, and vaccine safety information. The video features 8 case vignettes in which doctors demonstrate effective counseling strategies, incorporating the latest available evidence, to address the concerns of vaccine-hesitant parents.